Mesothelioma Disease and Lung Cancer as it Relates to Cigarette ...

One beneficial Examine towards bearing a variety of malboro smoking Any time Along with asbestos exposure is, The Interaction of Asbestos and Smoking in Lung Cancer Before we hit F. D. K. Liddell- Oxford magazines medicinal drugs- Might be Annals of a work HygieneVolume 1 out of 3, Issue5Pp. 341-356. Additional an excerpt: Abstract ? Both cigarette smoke and inhaled asbestos fibres can cause lung cancer, but the assessment of how these agents act in combination is a matter of great difficulty. In non-smokers, the condition is so rare that, in any cohort of asbestos workers, the standardised mortality ratio (SMR, that is the ratio of the numbers of deaths observed and expected) is quite imprecise. The SMR for smokers, with which it has to be compared, is also subject to sampling error, making the interaction even more unstable. This accounts for much of the variation that has bedevilled evaluation. The debate has been concentrated on two hypotheses: additive (asbestos and cigarette smoke act independently) and multiplicative (asbestos produces an effect proportional to the effect of smoking). The very few data available until 1977 failed to fit the former and fitted the latter only poorly. They would have fitted better a hypothesis of greater synergism, but the only one proposed was too convoluted. So the multiplicative model appeared the only alternative, and was deemed

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